carbamoyl phosphate การใช้

• The carbamoyl phosphate instead goes into the uridine monophosphate synthetic pathway.
• Citrulline is made from ornithine and carbamoyl phosphate by ornithine carbamoyltransferase.
• The increased orotic acid concentrations result from the buildup of carbamoyl phosphate.
• Carbamoyl phosphate synthase ( CPSase ) is a intermediate.
• Ornithine carbamoyltransferase ( OTCase ) catalyses the conversion of ornithine and carbamoyl phosphate to citrulline.
• Levels of urea cycle intermediates may be decreased, as carbamoyl phosphate cannot replenish the cycle.
• PMID 12664159 The carbamoyl phosphate synthase, dihydroorotase, aspartate carbamoyltransferase fusion is unique to unikonts.
• In this enzyme-catalyzed reaction, ATP and ammonium carbamate are converted to ADP and carbamoyl phosphate.
• The formation of the pyrimidine ring begins with the conversion of Aspartate to N-Carbamoylaspartate by undergoing a condensation reaction with carbamoyl phosphate.
• "' Carbamoyl Phosphate Synthetase I "'is a ligase enzyme located in the mitochondria involved in the production of urea.
• The synthesis of the pyrimidines CTP and UTP occurs in the cytoplasm and starts with the formation of carbamoyl phosphate from glutamine and CO 2.
• SIRT5 deacetylases and regulates carbamoyl phosphate synthetase ( CPS1 ), the rate-limiting and initiating step of the urea cycle in liver mitochondria.
• The biosynthesis of cyanide in the [ NiFe ]-hydrogenases proceeds from carbamoyl phosphate, which converts to cysteinyl thiocyanate, the CN  " donor.
• Ammonium carbamate can play a key role in the formation of carbamoyl phosphate, which is necessary for both the urea cycle and the production of pyrimidines.
• NAG can be used in the production of ornithine and arginine, two important amino acids, or as an allosteric cofactor for carbamoyl phosphate synthase ( CPS1 ).
• The large subunit in bacterial CPSase has four structural domains : the carboxy phosphate domain 1, the oligomerisation domain, the carbamoyl phosphate domain 2 and the allosteric domain.
• Next, aspartate carbamoyltransferase catalyzes a condensation reaction between aspartate and carbamoyl phosphate to form carbamoyl aspartic acid, which is cyclized into 4, 5-dihydroorotic acid by dihydroorotase.
• ATCase is a highly regulated enzyme that catalyses the first committed step in pyrimidine biosynthesis, the condensation of l-aspartate and carbamoyl phosphate to form N-carbamyl-L-aspartate and inorganic phosphate.
• Each of the catalytic domains is composed of two structural domains, the aspartate domain, which contains most of the residues responsible for binding aspartate, and the carbamoyl phosphate domain, which contains most of the residues that bind to carbamoyl phosphate.
• Each of the catalytic domains is composed of two structural domains, the aspartate domain, which contains most of the residues responsible for binding aspartate, and the carbamoyl phosphate domain, which contains most of the residues that bind to carbamoyl phosphate.